K. Verschueren, G. Tóth, D. Tourwé
1992
Citations
0
Influential Citations
31
Citations
Journal
Synthesis
Abstract
A rapid synthesis of 1,2,3,4-tetrahydro-7-hydroxyisoquinoline-3- carboxylic acid is given. Pictet-Spengler reaction on diiodo- or dibromo-substituted tyrosine (3-(3,5-dihalo-4-hydroxyphenyl)- 2-aminopropanoic acid), followed by catalytic dehalogenation gives the desired compound in high optical purity