Zhang Lian
2014
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Journal
Northwest Pharmaceutical Journal
Abstract
Objective To synthesize the unnatural amino acid(S)-2,6-dimethylphenylalanine.Methods 2,6-Dimethylbenzoic acid was reduced to produce 2,6-dimethylbenzyl alcohol,then the alcohol was brominated to generate 2,6-dimethylbenzy bromide.The bromide was then coupled with(S)-BPB-Ni-Gly complex to give(S)-Dmp-BPB-Ni complex,which was then decomposed by acid to obtain(S)-2,6-dimethylphenylalanine.Results(S)-2,6-dimethylphenylalanine was synthesized at a total yield of 33.6%.Conclusion This method has characteristics of cheap starting material and simple experimental procedure.