Zhou Li-hong, Xiang Guang-ya, Z. Han-ping
2006
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Journal
The Chinese Pharmaceutical Journal
Abstract
OBJECTIVE To improve the synthesis methods of vidarabine monophosphate.METHODS Vidarabine monophosphate was synthesized by vidarabine phosphorylation directly in the present of pyridine and acetonitrile.The pure products were obtained by crystallization.RESULTS The structure of vidarabine monophosphate was confirmed by UV,NMR and MS analysis.CONCLUSION This method is suitable for industrialization,with high yield the materials are easily obtained with high yield.