T. Miyazaki, S. Yokoshima, S. Simizu
Oct 13, 2007
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0
Influential Citations
55
Citations
Journal
Organic letters
Abstract
A synthetic route to vinblastine and its analogues with an ethynyl group, which features a stereoselective coupling of an 11-membered key intermediate with vindoline, is described. Transformations of the alkynyl moiety including a partial reduction as well as a Sonogashira coupling furnished a variety of analogues.