M. Morytko, Patrick Betschmann, Kevin R. Woller
Mar 15, 2008
Citations
0
Influential Citations
13
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A novel series of cyanoguanidine-piperazine P2X(7) antagonists was designed based upon the structure of A-740003. Structure-activity relationship (SAR) studies focused on the piperazine moiety and the right hand side substitution. Compounds were assayed for activity at human and rat P2X(7) receptors and compound 29 was found to possess potent activity (IC(50)=30-60 nM) at both species.