J. Raval
2009
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Scientia Pharmaceutica
Abstract
A variety of 2-(N'-benzoylhydrazino)-4-(substitutedphenyl)amino-6-pyrazin-2ylamino-1,3,5-triazines (7a–o) was synthesized from 2-aminopyrazine, isonicotinic acid hydrazide and cyanuric chloride. The structure of these compounds was confirmed by IR and NMR (H & C) spectral analysis and the newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among them, N'-{4-[(4-chlorophenyl)amino]-6-(pyrazin-2ylamino)-1,3,5-triazin-2-yl}benzohydrazide (7g), N'-{4-[(4-methoxyphenyl)amino]-6-(pyrazin-2-ylamino)-1,3,5-triazin-2-yl}benzo–hydrazide (7m) and 4-({4[2-(phenylcarbonyl)hydrazino]-6-(pyrazin-2-ylamino)-1,3,5-triazin-2-yl}amino)benzenesulfonamide (7o) showed the highest efficacy and exhibited >90% inhibition at a concentration of 0.0243 μM, 0.0266 μM and 0.0177 μM. The newly synthesized compounds were also evaluated for antimicrobial activity against a variety of bacterial strains and some of these compounds have shown significant antibacterial and antifungal activities as well.