G. Zhang, Y. Liu, X. Ma
Oct 1, 2011
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Chinese Chemical Letters
Abstract
Abstract A series of novel 2-hydrazinylpyrido[2,3- b ]pyrazin-3(4 H )-one derivatives were synthesized and evaluated for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro . Pharmacological data indicated that compounds 5b , 5c , 10a and 10g possessed marked cytotoxicity, especially 10a (with IC 50 values of 0.81, 2.56 and 1.63 μmol/L against A549, MDA-MB-231 and HT29 cell lines, respectively), which had emerged as a lead compound.