Ruswanto, A. M. Miftah, D. H. Tjahjono
2015
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0
Influential Citations
22
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Quality indicators
Journal
Procedia Chemistry
Abstract
Abstract Thioureas are important sulfur and nitrogen containing compounds and they are useful substances in drug research. In an effort to improve potential anticancer activities, two novel 1-benzoyl-3-methyl thiourea derivatives were designed and synthesized with substitution at aromatic positions of C-3, and C-4 of 1-benzoyl-3-methyl thiourea. Their structures were confirmed using IR, MS and 1 H-NMR. The in vitro cytotoxicity against HeLa cell lines were evaluated by the standard MTT assay. All of the compounds exhibited more potent cytotoxicity with IC50 values of 160–383 μg/mL stronger than hydroxyurea with IC50 value of 428 μg/mL.