Aaron B. Beeler, R. Gadepalli, S. Steyn
Nov 17, 2003
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0
Influential Citations
25
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
The substrate properties of three beta-fluoro-4-phenyl-1,2,3,6-tetrahydropyridines related to the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine have been examined in an effort to evaluate the contribution of electronic parameters to the MAO-B catalyzed allylic-alpha-carbon oxidation of the tetrahydropyridinyl system. The design, synthesis, and biological evaluation of these analogues are presented and correlations to amine ionization potentials versus substrate activity are discussed.