D. Yung, D. E. Mahony, L. Whitehouse
Mar 1, 1971
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
Thirty new hydrazones of 1-phenyl-, 1-benzyl-, and 1-benzhydryl-4-aminopiperazines were prepared and tested for in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Clostridium perfringens, and Mycobacterium phlei, and for antifungal activity against Saccharomyces cerevisiae and Candida albicans. Activities were detected in seven compounds. A bactericidal action against B. subtilis and Cl. perfringens was noted in 1-phenyl-4-(5-nitro-2-furfurylideneamino)piperazine. 1-Benzyl-4-(5-nitro-2-furfurylideneamino)piperazine and 1-benzhydryl-4-(5-nitro-2-furfurylideneamino)piperazine were found to suppress the growth of B. subtilis. 1-Benzhydryl-4-isonicotinylideneaminopiperazine showed a broad spectrum of activity, inhibiting the growth of M. phlei, S. aureus, B. subtilis, and S. cerevisiae. 1-Benzhydryl-4-nicotinylideneaminopiperazine had a bacteriostatic effect on M. phlei, while 1-benzyl-4-[4-(4-methoxyphenyl)-3-butene-2-ylideneamino]piperazine exhibited a bactericidal action against the same bacteria. A bacteriostatic effect on S. aureus was observed in 1-benzyl-4-(5-nitro-2-hydroxybenzylideneamino)piperazine. None of the hydrazones showed antimicrobial activity against E. coli, P. aeruginosa, and C. albicans.