A. Foroumadi, S. Emami, S. Pournourmohammadi
Dec 1, 2005
Citations
2
Influential Citations
57
Citations
Quality indicators
Journal
European journal of medicinal chemistry
Abstract
A series of 2-(1-methyl-5-nitroimidazol-2-yl)-5-(1-piperazinyl, 1-piperidinyl and 1-morpholinyl)-1,3,4-thiadiazoles (3a-g) were synthesized and evaluated for in vitro leishmanicidal activity against Leishmania major promastigotes. The leishmanicidal data revealed that compounds 3a-g had strong and much better leishmanicidal activity than the reference drug pentostam. Compound 3c (piperazine analog) was the most active compound (IC50=0.19 microM).