F. Vos, P. Santens, G. Slegers
May 1, 2000
Citations
0
Influential Citations
1
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Donepezil (1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl-]piperidine), a potent acetylcholine esterase inhibitor, was labelled with [11C]iodomethane by O-methylation of the O-6′-desmethyl precursor. Synthesis, purification and formulation were performed in approximately 30 min with an average specific activity of 39.5 GBq/μmol at EOS. The total activity available for applications was 7.5–11.1 GBq. Copyright © 2000 John Wiley & Sons, Ltd.