Hiroaki Wada, R. Iwata, T. Ido
Jul 1, 2000
Citations
0
Influential Citations
15
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
Fluorine-18 labeled 1-[20-fluoro-1-(hydroxymethyl)ethoxy]-methyl-2-nitroimidazole ([ 18 F]FENI), a novel, potential radiotracer for imaging hypoxic tissue by PET, was synthesized. The [ 18 F]FENI was prepared by nucleophilic 18 F-fluorination of the precursor, 1-[2-(toluene-4-sulfoxy)-1-(acetoxymethyl)ethoxy]methyl-2-nitroimidazole, followed by deprotection and HPLC purification. Radiochemically pure [ 18 F]FENI was obtained in overall yields of 3-11% (EOB) with specific activity of >26 GBq/μmol (EOS) within 90 min.