Su Wei-ke
2008
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Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To study the synthetic method of 3-(2-Chloro-6-fluoro phenyl)-5-methylisoxazole-4-carbonyl chloride.METHODS The objective compound was synthesized by steps of oximation,chlorination,cyclization,hydrolysis,acyl chlorination,starting from 2-chloro-6-fluorobenzaldehyde.RESULTS The chemical structure of synthetic products was confirmed by IR,1H-NMR,13C-NMR and MS,the total yield was amount to 60.2%.CONCLUSION This synthetic route is practical with high yield and low cost.