Constantinos D. Antoniadis, S. Hadjikakou, N. Hadjiliadis
Nov 1, 2004
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0
Influential Citations
32
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Journal
European Journal of Inorganic Chemistry
Abstract
The reaction of 2-mercaptopyridine (C5H5NS or PYSH) with diiodine in a molar ratio of 1:2 in dichloromethane led to the oxidation and dimerization of the ligand and formation of [(PYS−PYSH)+·I3−]. The compound was characterised by elemental analysis, DTA-TG, FT-Raman, FT-IR, UV/Vis and 1H NMR spectroscopy. The crystal structure of the complex has been determined by X-ray diffraction at 293(2) K. The compound [(C5H4NS−SNC5H5)I3] is monoclinic with the space group P21 and a = 8.230(2) A, b = 35.708(7) A, c = 11.369(2) A, β = 91.86(3)° and Z = 8. The results are discussed in relation to the mechanism of action of antithyroid drugs. The easy oxidation of PYSH by I2 to form the monocationic disulfide complex [(PYS−PYSH)+·I3−] is similar to the case of the antithyroid drug methimazole (MMI) and may indicate that PYSH might also possess antithyroid properties similar to those of MMI. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)