Dimitris Matiadis, Valentina Stefanou, G. Athanasellis
Apr 26, 2013
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0
Influential Citations
8
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Journal
Monatshefte für Chemie - Chemical Monthly
Abstract
A series of coumarin and quinolinone-3-aminoamide derivatives was synthesized and evaluated for its potency in inhibition of cancer cell growth. The structure of N-[2-(dimethylamino) ethyl]-4-hydroxy-2-oxo-1-phenyl-1,2-dihydroquinoline-3-carboxamide was unambiguously confirmed by X-ray diffraction analysis, which revealed the cis conformation of the amide bond resulting from the presence of two intramolecular hydrogen bonds.Graphical Abstract