Jiang Shen-de
2010
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Fine chemicals
Abstract
3,4-Dimethoxyphenylacetonitrile was employed as the starting material to prepare 3,4-dimethoxyphenylethylamine and 3,4-dimethoxyphenylacetic acid via hydrolysis and hydrogenation reduction,respectively.The resulting two intermediates were reacted to produce the amide,which underwent Bischler-Napieralski cyclization,potassium borohydride reduction,and Pictet-Spengler reaction with formaldehyde to give racemic xylopinine in an overall yield of 47%.