Liu Ya-hu
2010
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Journal
Fine chemicals
Abstract
tert-Butyl-4-(4-amino-3-methyl-5-nitrophenyl)piperazine-1-carboxylate(1) was synthesized in 52% yield through a simple lost-cost amination of 4-iodo-2-methyl-6-nitroaniline,in which inexpensive CuI,ethylene glycol and potassium phosphate were used as catalyst,ligand,and base,respectively.The structure of the synthesized compound 1 was characterized with ESI-MS,1HNMR and elementary analysis.Compound 1 is an important intermediate for the synthesis of biologically active benziimidazole compounds.