X. Yang
2008
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Journal
Fine chemicals
Abstract
(S)-2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole is a key intermediate for the preparation of chiral proton pump inhibitors. A synthesis route including nine steps for the preparation of this compound from 2,3-dimethylpyridine was studied. The optical purity of the product was analyzed by chiral HPLC and the e.e. value of the target compound is 95.5%.Structures of the reaction products were characterized by IR,UV,MS and 1HNMR.