Yi Yang, Min Zhang, Yi‐Wei Zhu
Jul 1, 2013
Citations
0
Influential Citations
5
Citations
Journal
Chinese Journal of Chemistry
Abstract
Ethyl 4,4,4-trifluoro-3-oxo-butyrate reacted with 2,6-dimethyl-3,5-diacetyl-pyridine 1 in the presence of NaOC2H5 at 0°C to give 2,6-dimethyl-3,5-bis(4,4,4-trifluoro-1,3-oxo-butyl)-pyridine (2a) in good yield. Cyclization reaction of 2a and aryl imidoyl chlorides 5a–5i, obtained from chlorination of aryl oximes with N-chlorosuccimide, afforded 2,6-dimethyl-3,5-bis[(3-aryl-5-trifluoromethyl)-isoxazol-4-carbonyl]-pyridine derivatives 6a–6i.