Zhang Yi-fan
2010
Citations
0
Influential Citations
1
Citations
Journal
Chemistry World
Abstract
Using phenylacetic acid as raw material,2-bromo-1-(4-fluorophenyl)-2-phenylethanone was prepared by bromination with HBr and H_2O_2 from 1-(4-fluorophenyl)-2-phenylethanone.4-Fluoroα-(2-methyl-1-oxopropyl)-γ-oxo-N,β-diphenyl-benzenebutanamide,the key intermediate of atorvastatin calcium,was synthesized by condensation of 2-bromo-1-(4-fluorophenyl)-2-phenylethanone and 4-methyl-3-oxopentanoic acid anilide.The overall yield was 57.3%.The product was characterized by()~1H NMR and MS spectroscopy.