Y. Yoshimura, K. Saitoh, N. Ashida
Mar 10, 1994
Citations
0
Influential Citations
13
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract 2'-β-Spiroepoxy-uridine was obtained from the reaction between 2'-ketouridine and dimethylsulfoxonium methylid. The oxirine ring was cleaved by KFHF and the resulting tertiary hydroxyl group was removed by radical deoxygenenation using a t -methyl oxalyl-tributyltin hydride system to give 2-deoxy-2- C -fluoromethyl-1-β-D-arabinofuranosyl-uracil derivative 7 . Finally, the uracil moiety was converted to a cytosine counterpart, followed by deprotection to yield the title compound.