Y. Yuasa, Y. Yuasa
Mar 26, 2004
Citations
0
Influential Citations
7
Citations
Journal
Organic Process Research & Development
Abstract
2,3,4,6-Tetra-O-acetyl-1-O-(2-propenyl)-β-d-glucopyranoside (1a), which is a useful raw material in the synthesis of a bioactive agent, has been synthesized in 50% yield by reacting β-d-glucose pentaacetate and 3 mol equiv of an allyl alcohol with 0.9 mol equiv of ZnCl2 in toluene at 80 °C for 2 h followed by recrystallization from diisopropyl ether. This method is suitable for the large-scale preparation of 1a due to its efficiency, safety, and cost-effectiveness.