Zhuo Zeng, J. Shreeve
Aug 1, 2009
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0
Influential Citations
3
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract 2,2,6,6-Tetrafluoro-4-phenylmethylmorpholin-3-ones are obtained from a new single step, preparative route by reacting triethylene glycol di(trifluoromethanesulfonate), which contains poly –CF2O– groups, with benzylamine. Reaction of trifluoromethylsulfonate and trifluoromethoxy derivatives with benzylamine gave either the nucleophilically-substituted product or the product resulting from the basic hydrolysis of the difluoromethoxy group. Replacement of a fluoroether chain by a fluoroalkane gave rise to fluorinated phenylmethylpiperidine and phenylmethylazepine via the combination of trifluoromethanesulfonic fluoroalkyldiyl esters and benzylamine.