Chen Zhan-guo
2008
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Journal
Northwest Pharmaceutical Journal
Abstract
Objective To investigate a new method of synthesis of 2-benzyl-5-hydroxyl-3,4-dihydroisoquinolin-1(2H)-one.Method 2-benzyl-5-hydroxy-6-methoxy-3,4-dihydro-isoquinolin-1(2H)-one(1)was synthesized from methyl 3-hydroxy-4-methoxyben-zoate via allyl etherification,Claisen rearrangement,oxidation,reductive amination and amidation.Reductive amintion and ami-nolysiswere completed in one-pot.Results A new derivative of 3,4-dihydro-isoquinolin-1(2H)-one was synthesized and its structure was identified by IR and 1HNMR.Conclusion The designed synthetic route was mild and simple in operation with higher yield.