Shang Zhi-cai
2006
Citations
0
Influential Citations
0
Citations
Journal
Chemistry World
Abstract
A convenient,high-yield synthesis of 1-O-acetyl-3,5-di-o-(p-chlorobenzoyl)-2-deoxy-α,β-D-ribofuranoside from 2-deoxy-D-ribose was reported.The product was a very important medical intermediate.Its anomers were separated by column chromatography.The optimum conditions were as follows: methyl-3,5-di-o-(p-chlorobenzoyl)-2-deoxy-α,β-D-ribofuranoside:acetic anhydride,1∶4.4;2 mL conc.sulfuric acid;temperature of solution when adding conc.sulfuric acid,(-2°C);hydrolysis temperature,(6°C).The yield was above 84.14%.The separated α and β anomers were characterized by()~1H NMR and melting point.