Bao Xiu-rong
2009
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Journal
Journal of tianjin University of Technology
Abstract
1,4-Bialiphatic amino-5,8-dihydroxy anthraquinones as an intermediate of an anticancer drug were synthesized by the condensation and oxidation of leuco-1,4,5,8-tetrahydroxyanthraquinone with aliphatic amine.Their structures were determined by FTIR and 1H-NMR analysis.Anti-cancer activities of these compounds were roughly tested in vitro.Such 1,4-bi[2(dimethylamio)-ethylamino]-5,8-dihydroxy-anthraquinone derivates made this a versatile strategy for the lead compound of anti-tumor drug.