Ouyang Gui-ping
2012
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Journal
Fine chemicals
Abstract
Four compounds of 4-(3′-chlorophenylamino)-6-methoxy quinazoline compounds(Ⅰa~Ⅰd),including 7-[3-(4-nitrophenoxy)propoxy]-N-(3′-chlorophenyl)-6-methoxyquinazolin-4-amine(Ⅰa),7-[3-(3-nitrophenoxy)propoxy]-N-(3′-chlorophenyl)-6-methoxyquinazolin-4-amine(Ⅰb),4-{3-[4-(3′-chlorophenylamino)-6-methoxyquinazolin-7-yloxy]propoxy}-3-methoxybenzaldehyde(Ⅰc),3-{3-[4-(3′-chlorophenylamino)-6-methoxyquinazolin-7-yloxy]propoxy}-4-methoxybenzaldehyde(Ⅰd),were synthesized from N′-[5-(3-chloropropoxy)-2-cyano-4-methoxyphenyl]-N,N-dimethylformamidine by cyclization and etherization in the yields of 51.3%,60.3%,85.4% and 79.4% respectively.Their structures were characterized by means of IR,1HNMR,13CNMR,MS and elemental analysis.Preliminary bioassay indicates that some compounds possess antitumor activity to Bcap-37 cells in vitro by MTT method.The antiproliferation activity of compound Ⅰa to Bcap-37 cells at the concentration of 10 μmol/L was 83.4%.