Jing Sun, Qun-yan Wu, E. Xia
Dec 1, 2010
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Influential Citations
5
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Journal
Synthesis
Abstract
Polyfunctionalized trans-2,3-dihydrothiophenes are efficiently synthesized from the four-component reactions of thiazolidine-2,4-dione, aromatic aldehydes, secondary amines, and pivaloylacetonitrile. The reaction mechanism involves Knoevenagel condensation, Michael addition, and characteristic ring-opening of thiazolidine-2,4-dione followed by an intramolecular ring-closure process.