Gao Wen-tao
2012
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Journal
Journal of Bohai University
Abstract
Salicylaldehyde(1) was brominated using liquid bromine as brominating agent in the presence of ethanol as solvent at 10 ℃ to afford mono-substituted 5-bromosalicylaldehyde(2) in 82.7% yield.When NBS(N-bromosuccinimide) was used as a brominating agent in the presence of PEG-400 as solvent at room temperature,the disubstituted 3,5-dibromosalicylaldehyde(3) was obtained in 74.1% yield.Similarly,when NBS was replaced with NCS(N-chlorosuccinimide) as a chlorination agent under the same reaction conditions,the corresponding 3,5-dichlorosalicylaldehyde(4) was obtained in 34.8% yield.