Qian Hua, Li Da-bin, W. Liang
Sep 10, 2009
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Journal
Chinese Journal of Applied Chemistry
Abstract
Methoxy-7H-Furo(3,2-g)(1)benzopyran-7-One is one kind of linear Furanocoumarins, which shows a wide range of biological properties. A simple method for its synthesis was proposed in this paper, which was accomplished from phloroglucinol and ethyl propiolate as original materials by etherification, iodination, Pechmann condensation, coupling reaction, hydrolysis and decarboxylation. Intermediates and the target compound were characterized by 1 H NMR, IR and MS. The proper reaction conditions were optimized by experiments and the feasibility of route was also studied. All reactions were preceded under normal pressure with mild condition and relatively simple post-processing, which shows a new route for the preparation of furanocoumarins.