Jin Yin
2015
Citations
0
Influential Citations
1
Citations
Journal
Chemical Research and Application
Abstract
( 3S,4S)-4-( Dibenzylamino)-3-hydroxy-6-methyl-heptanoic acid was synthesized from L-Leucine by protection of amino and carboxyl group to give( S)-2-( dibenzylamino)-4-methylbenzyl valerate,which was subjected to nucleophilic substitution with acetontrile and stereoselective reduction with Na BH4 to afford( 3S,4S)-4-( dibenzylamino)-3-hydroxy-6-methylheptanenitrile,followed by oxidation with hydrogen peroxide to give( 3S,4S)-4-( dibenzylamino)-3-hydroxy-6-methylheptanoic acid. Finally,deprotection of benzyl group in presence of Pd( OH)2/ C-H2 to achieve( 3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid in an overall yield of about 33. 6%.