Parvin Kumar, J. Mohan, J. K. Makrandi
Nov 1, 2007
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Journal
ChemInform
Abstract
Synthesis of 2-(3'-bromophenyl)-5-(p-bromophenyl) thiazolo[3,2-b]-s-triazoles 4 has been achieved starting from the appropriate 5-mercapto-3-(3'-bromo phenyl)-s-triazole 2. Compound 2 on condensation with α-haloketones gives the ketones 3 which on cyclization with PPA afford 5-(p-bromophenyl)-2-(3'-bromophenyl)thiazolo[3,2-b]-s-triazoles 4 and not the isomeric thiazolo[2,3-c]-s-triazoles 6. This has been established by an unequivocal synthesis of 6 through POCl 3 cyclization of 3'-bromobcnzoylhydrazino-4-p-bromophenylthiazole hydrobromide 5. The diuretic, antibacterial and antifungal activities of some of the compounds have also been evaluated.