Chen Hong-bo
2009
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Journal
Journal of Eastern Liaoning University
Abstract
5-acetylamino-1,3,4-thiadiazole-2-sulfonyl chloride compound was synthesized using 5-amino-2-mercapto-1,3,4-thiadiazole which was acidylated and oxidized with gaseous chlorine.By its reaction with N-methyl piperazine and aniline,two new target produces were obtained as 5-acetylamino-1,3,4-thiadiazole-(2-N-methyl piperazine) sulfonylanilin and 5-acetylamino-1,3,4-thiadiazole-(2-sulfonyl)-aniline.The results showed that the best acidylation conditions for raw materials were as follows: the proportion of 5-amino-2-mercapto-1,3,4-thiadiazole and acetic anhydride was n:n=1∶1.25;reaction temperature was 70 ℃;the amount of acetic acid was 12ml.The target product recovery rate was more than 88%.The best conditions for targets are as follows: ethanol was used as the solvent,material ratio was 1:2.The recovery rate under room temperature was more than 88%,and the product purity was more than 97%.Target products were characterized with IR,H-NMR,LC-MS.