Song Yi-li
2007
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Journal
Chemical Intermediates
Abstract
Comparing to different reaction methods, the method starting from 1,3-dimethyladamantane was certified with the memantine hydrochloride synthesized by bromination ,acetimidolation, hydrolysis and acidation.Bromination was run under reflux for 12h, molar ratio of 1,3-dimethyladamantane to bromine was 1∶1.5;hydrolysis was carried out with molar ratio of glycol to water 10∶1 as solvent at 150℃ for 12h, molar ratio of 1-acetimdolyl-3,5-dimethyladmantane to sodium hydroxide was 1∶5.The overall yield reached 81.5%.Structures of the product were characterized by IR,ESI,1HNMR and13CNMR.