You Zhou, Peng Zhao, Xiao-Xiao Yu
Oct 11, 2020
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Journal
Organic letters
Abstract
A novel method for the synthesis of 5H-benzo[a]fluoren-5-one from inactive nonterminal 1,6-alkynes through a free radical tandem bicyclization process has been established. This process achieved a continuous cyclization triggered rarely by the α-position of α,β-unsaturated ketones. The reaction constructed three C-C bonds in one step with the readily accessible substrates and excellent substrate compatibility.