J. Spetzler, T. Hoeg-Jensen
Jul 15, 2007
Citations
0
Influential Citations
5
Citations
Journal
Bioorganic & medicinal chemistry
Abstract
4,5-dimethoxy-2-mercaptobenzylamine (Dmmb) has been protected by acetamidomethyl (Acm) and incorporated into a peptide thioester for use in tandem native chemical ligation. Upon ligation between the thioester and a Cys-peptide, Acm was removed from Dmmb using silver acetate, and a second ligation reaction was done at the Dmmb position. Dmmb removal using TFMSA-TFA effected overall tandem ligation at X-Cys and Gly-Gly.