Ana Bornadiego, Jesús Díaz, C. Marcos
May 6, 2019
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0
Influential Citations
10
Citations
Journal
The Journal of organic chemistry
Abstract
We report an easy multicomponent synthesis of polycyclic isoindoles from cyclic 1,3-dicarbonyls, aldehydes, isocyanides, and maleimides. The key step consists of the one-pot Diels-Alder trapping of a reactive 2-aminofuran intermediate, formed by a sequence of a Knoevenagel condensation and a [4+1] cycloaddition. Moreover, a further microwave-promoted dehydrogenative N-C bond forming reaction allows the straightforward synthesis of a natural product like isoindolocarbazole, validating the utility of our methodology to obtain isoindoles as useful intermediates for the synthesis of complex polycyclic molecules.