Ahmed G. Eissa, J. Blaxland, Rhodri O. Williams
Feb 22, 2016
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Journal of Enzyme Inhibition and Medicinal Chemistry
Abstract
Abstract The synthesis of a series of benzimidazole-N-benzylpropan-1-amines and adenine-N-benzylpropan-1-amines is described. Subsequent evaluation against two strains of the anaerobic bacterium Clostridium difficile was performed with three amine derivatives displaying MIC values of 16 μg/mL. Molecular docking studies of the described amines determined that the amines interact within two active site pockets of C. difficile methionyl tRNA synthetase with methoxy substituents in the benzyl ring and an adenine biaryl moiety resulting in optimal binding interactions.