David Roberson, David P. Roberson, David Roberson
Sep 1, 2011
Citations
6
Influential Citations
78
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Journal
British Journal of Pharmacology
Abstract
BACKGROUND AND PURPOSE We have developed a strategy to target the permanently charged lidocaine derivative lidocaine N‐ethyl bromide (QX‐314) selectively into nociceptive sensory neurons through the large‐pore transient receptor potential cation channel subfamily V (TRPV1) noxious heat detector channel. This involves co‐administration of QX‐314 and a TRPV1 agonist to produce a long‐lasting local analgesia. For potential clinical use we propose using lidocaine as the TRPV1 agonist, because it activates TRPV1 at clinical doses.