H. Shigemori, Cecilia A. Sakurai, H. Hosoyama
Feb 26, 1999
Citations
0
Influential Citations
15
Citations
Quality indicators
Journal
Tetrahedron
Abstract
Abstract Three new taxoids, taxezopidines J (1), K (2), and L (3), have been isolated from seeds of the Japanese yew Taxus cuspidata Sieb. et Zucc. and the structures were elucidated on the basis of spectroscopic data and chemical means. Taxezopidines K (2) and L (3) markedly inhibited Ca2+-induced depolymerization of microtubules, while taxuspine D (4), a known taxoid from the yew, induced unusual shape change of mitotic spindles like taxol.