A. Nikolakakis, G. Caron, A. Cherestes
Jun 1, 2000
Citations
0
Influential Citations
21
Citations
Journal
Bioorganic & medicinal chemistry
Abstract
An efficient conversion of Taxus canadensis abundant taxane, 9-dihydro-13-acetylbaccatin III to baccatin III is described. Since the synthesis of paclitaxel from baccatin III has been reported, this work can be used for additional supply of this powerful anticancer drug. In addition, new taxanes derived from skeletal rearrangements originating from oxidation reduction reactions of the Canadian yew major taxane, are reported.