Min Yang, Xin Hu, Banlai Ouyang
Jun 21, 2019
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron
Abstract
Abstract In this work, we described a new synthetic route of 3-bromo-1,2-dihydroquinoline derivatives based on the TBAB/Oxone-mediated radical 6-endo-trig ortho-cyclization of 2-alkynylbenzamide. The reaction proceeded smoothly with moderate functional group tolerance and high reaction efficiency. It is believed that radical addition, 6-endo-dig cyclization, and oxidation are all involved in the reaction processes. Furthermore, we successfully demonstrated the usability of these derivatives in further functionalization.