Yan Min
2008
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To study the synthesis of pipecuronium bromide.Methods pipecuronium bromide was synthesized from 5α-androsterone through tosylation,elimination,esterification of enol,epoxidation by m -chloroperbenzoic acid,ring opening with N -methylpiperazine,reduction,acetylation, N -methylation with methyl methanesulfonate,then substitution with LiBr.Results and conclusion Chemical structure of pipecuronium bromide was confirmed by 1H-NMR, 13 C-NMR,IR and MS,the total yield is 13.3%.The synthetic method is feasible to industrial production.