E. Cummings
Jul 1, 1969
Citations
0
Influential Citations
24
Citations
Quality indicators
Journal
The Journal of investigative dermatology
Abstract
N-octylamine was applied to the surface of the volar forearm of 20 volunteers at environmental temperatures, of 35°, 65°, 95°, and 115° F. The amine was dissolved in ethylene glycol to make solutions of 10, 25, and 50%. These solutions were applied in droplets of 30µg, and the vasodilatory effect as the end-point of skin penetration was measured by photoelectric plethysmography. The rate of penetration increased with temperature and concentration. N-octylamine induced wheal formation and erythema, and the increase in cutaneous blood flow was found to be mainly in area of the wheal. It was proposed that the effect of temperature on penetration involved epidermal factors.