L. Xiao-jun
2011
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Journal
Journal of Hebei University of Technology
Abstract
2-amino-6-methoxybenzothiazole is a key intermediate of dyes,and it is also a key intermediate of Firefly Luciferin.2-amino-6-methoxybenzothiazole was synthesized by cyclization reaction of anisidine and sodium thiocyanate catalyzed by Br2-CH3COOH.Ammonium thiocyanate was substituted by sodium thiocyanate and gradient temperature control was used in this reaction.The reaction time was reduced to 5 h,and ammonium thiocyanate was substituted by sodium thiocyanate.In this way,the reaction is more suitable for industrial application.The yield was 87.8% with purity 99%(HPLC).The structure was confirmed by 1H NMR.