S. Q. Cohlan, D. Kitay
Mar 1, 1965
Citations
0
Influential Citations
23
Citations
Journal
The Journal of pediatrics
Abstract
Vincaleukoblastine (VLB), a mitosis-inhibiting chemotherapeutic agent is teratogenic in the pregnant rat, producing a 9 per cent incidence of gross developmental malformations. Transplacentally acquired VLB inhibits cell mitosis in fetal tissues as evidenced by a sixfold increase in mitotic figures after a single injection of VLB. Glutamic acid which inhibits the effect of VLB in tissue culture does not protect the rat fetus from its teratogenic effect.