Songjin Guo, Qian Wang, Yan Jiang
Oct 31, 2014
Citations
0
Influential Citations
41
Citations
Journal
The Journal of organic chemistry
Abstract
A tert-butyl peroxybenzoate (TBPB)-promoted direct α-methylation of 1,3-dicarbonyl compounds has been developed, providing α-methyl derivatives in moderate to good yields. In this procedure, TBPB plays a dual role, serving as both the methyl source and radical initiator. This work represents a key complement to the traditional α-methylation of 1,3-dicarbonyl compounds using methyl iodide.