M. Löw, L. Kisfaludy, E. Jaeger
Dec 1, 1978
Citations
0
Influential Citations
3
Citations
Journal
Hoppe-Seyler's Zeitschrift fur physiologische Chemie
Abstract
The tert-butylation of free tryptophan under simulated conditions of acidolytic cleavage of protecting groups being based on a tert-butyl moiety does finally yield the tri-substituted amino acid as a main product, namely 2,5,7-tri-tert-butyltryptophan. The structural elucidation of this substance and other tert-butylated products, which were isolated mostly in a pure form, was achieved by means of spectroscopic methods, in particular mass spectrometry and nuclear magnetic resonance spectroscopy.