Yucai Tang, Ye Zhang, Kai‐Fang Wang
Jun 17, 2015
Citations
0
Influential Citations
54
Citations
Journal
Organic & biomolecular chemistry
Abstract
A facile synthetic route towards pharmaceutically interesting β-keto-sulfone derivatives by tetrabutylammonium iodide (TBAI)/tert-butyl hydroperoxide (TBHP) mediated oxidative coupling of readily prepared enamides with economical sulfonylhydrazides is described. The corresponding β-keto-sulfone compounds were obtained in moderate to good yields. The present method is metal-free and base-free and shows tolerance to a variety of functional groups.